We are aware of a tape compartment issue with the DYMO LabelWriter 450 Duo, related to the recent Windows 10 software update (KB5015807). Please know that our team is working on a solution. We apologize for any inconvenience.
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Supports all LabelWriter® 5 series, 450 series, 4XL, and LabelManager® 280, 420P and 500TS®