We are aware of a tape compartment issue affecting the DYMO LabelWriter 450 Duo. This is related to the recent Windows 10 software update (KB5015807). DYMO would like to apologize for any inconvenience caused and offer this step-by-step guide including the most common solutions. If this does not solve the issue, please do not hesitate to Contact Us directly.
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Support all with all 450 series/4XL, 550 series/5XL and LabelManagers